USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: PRP19_HUMAN USC-OGP 2-DE database:  PRP19_HUMAN PRP19_HUMAN General information about the entry View entry in simple text format Entry name PRP19_HUMAN Primary accession number Q9UMS4 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Pre-mRNA-processing factor 19 {ECO:0000305}; EC=2.3.2.27 {ECO:0000269|PubMed:11435423}; AltName: Full=Nuclear matrix protein 200 {ECO:0000303|PubMed:11082287}; AltName: Full=PRP19/PSO4 homolog {ECO:0000303|PubMed:12960389}; Short=hPso4 {ECO:0000303|PubMed:12960389}; AltName: Full=RING-type E3 ubiquitin transferase PRP19 {ECO:0000305}; AltName: Full=Senescence evasion factor {ECO:0000303|PubMed:16332694};. Gene name Name=PRPF19 {ECO:0000312|HGNC:HGNC:17896} Synonyms=NMP200 {ECO:0000303|PubMed:11082287}, PRP19 {ECO:0000303|PubMed:11435423}, SNEV {ECO:0000303|PubMed:16332694} Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1150: pI=6.41; Mw=55186 SPOT OGP-1312: pI=5.04; Mw=21529 SPOT OGP-1318: pI=5.55; Mw=19701 SPOT OGP-1331: pI=5.13; Mw=16684 SPOT OGP-1335: pI=5.02; Mw=16085 Cross-references UniProtKB/Swiss-Prot Q9UMS4; PRP19_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PRP19_HUMAN Primary accession number Q9UMS4 Sequence was last modified on  May 1, 2000 (version 1) Annotations were last modified on  March 15, 2017 (version 154) Name and origin of the protein Description RecName: Full=Pre-mRNA-processing factor 19 {ECO:0000305}; EC=2.3.2.27 {ECO:0000269|PubMed:11435423}; AltName: Full=Nuclear matrix protein 200 {ECO:0000303|PubMed:11082287}; AltName: Full=PRP19/PSO4 homolog {ECO:0000303|PubMed:12960389}; Short=hPso4 {ECO:0000303|PubMed:12960389}; AltName: Full=RING-type E3 ubiquitin transferase PRP19 {ECO:0000305}; AltName: Full=Senescence evasion factor {ECO:0000303|PubMed:16332694}; Gene name Name=PRPF19 {ECO:0000312|HGNC:HGNC:17896} Synonyms=NMP200 {ECO:0000303|PubMed:11082287}, PRP19 {ECO:0000303|PubMed:11435423}, SNEV {ECO:0000303|PubMed:16332694} Encoded on Name=PRPF19 {ECO:0000312|HGNC:HGNC:17896}; Synonyms=NMP200 {ECO:0000303|PubMed:11082287}, PRP19 {ECO:0000303|PubMed:11435423}, SNEV {ECO:0000303|PubMed:16332694 Keywords 3D-structure; Acetylation; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; DNA damage; DNA repair; Lipid droplet; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat; Spliceosome; Transferase; Ubl conjugation pathway; WD repeat. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AJ131186; CAB51857.1; -; mRNA EMBL BC008719; AAH08719.1; -; mRNA EMBL BC018665; AAH18665.1; -; mRNA EMBL BC018698; AAH18698.1; -; mRNA CCDS CCDS7995.1; -; . RefSeq NP_055317.1; NM_014502.4; . UniGene Hs.502705; -; . PDB 4LG8; X-ray; 1.89 A; A=169-504 PDBsum 4LG8; -; . ProteinModelPortal Q9UMS4; -; . SMR Q9UMS4; -; . BioGrid 118151; 173; . DIP DIP-32978N; -; . IntAct Q9UMS4; 42; . MINT MINT-1454442; -; . STRING 9606.ENSP00000227524; -; . iPTMnet Q9UMS4; -; . PhosphoSitePlus Q9UMS4; -; . SwissPalm Q9UMS4; -; . BioMuta PRPF19; -; . DMDM 55976619; -; . REPRODUCTION-2DPAGE IPI00004968; -; . SWISS-2DPAGE Q9UMS4; -; . EPD Q9UMS4; -; . MaxQB Q9UMS4; -; . PaxDb Q9UMS4; -; . PeptideAtlas Q9UMS4; -; . PRIDE Q9UMS4; -; . DNASU 27339; -; . Ensembl ENST00000227524; ENSP00000227524; ENSG00000110107; . GeneID 27339; -; . KEGG hsa:27339; -; . UCSC uc001nqf.4; human; . CTD 27339; -; . DisGeNET 27339; -; . GeneCards PRPF19; -; . HGNC HGNC:17896; PRPF19; . HPA CAB012448; -; . HPA HPA038051; -; . HPA HPA059070; -; . MIM 608330; gene; . neXtProt NX_Q9UMS4; -; . OpenTargets ENSG00000110107; -; . PharmGKB PA134941355; -; . eggNOG KOG0289; Eukaryota; . eggNOG ENOG410XPQV; LUCA; . GeneTree ENSGT00860000133707; -; . HOGENOM HOG000177308; -; . HOVERGEN HBG053697; -; . InParanoid Q9UMS4; -; . KO K10599; -; . OMA SEDQYWA; -; . OrthoDB EOG091G05AH; -; . PhylomeDB Q9UMS4; -; . TreeFam TF105919; -; . Reactome R-HSA-6781823; Formation of TC-NER Pre-Incision Complex; . Reactome R-HSA-6781827; Transcription-Coupled Nucleotide Excision Repair (TC-NER); . Reactome R-HSA-6782135; Dual incision in TC-NER; . Reactome R-HSA-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER; . Reactome R-HSA-72163; mRNA Splicing - Major Pathway; . SignaLink Q9UMS4; -; . UniPathway UPA00143; -; . ChiTaRS PRPF19; human; . GeneWiki PRPF19; -; . GenomeRNAi 27339; -; . PRO PR:Q9UMS4; -; . Proteomes UP000005640; Chromosome 11; . Bgee ENSG00000110107; -; . CleanEx HS_PRPF19; -; . ExpressionAtlas Q9UMS4; baseline and differential; . Genevisible Q9UMS4; HS; . GO GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; IDA:MGI; . GO GO:0005811; C:lipid particle; IEA:UniProtKB-SubCell; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0016607; C:nuclear speck; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0000974; C:Prp19 complex; IDA:UniProtKB; . GO GO:0035861; C:site of double-strand break; IDA:UniProtKB; . GO GO:0005819; C:spindle; IEA:UniProtKB-SubCell; . GO GO:0071006; C:U2-type catalytic step 1 spliceosome; IBA:GO_Central; . GO GO:0042802; F:identical protein binding; IPI:BHF-UCL; . GO GO:0061630; F:ubiquitin protein ligase activity; IMP:UniProtKB; . GO GO:0034450; F:ubiquitin-ubiquitin ligase activity; IDA:MGI; . GO GO:0034613; P:cellular protein localization; IMP:UniProtKB; . GO GO:0006303; P:double-strand break repair via nonhomologous end joining; IMP:UniProtKB; . GO GO:0000349; P:generation of catalytic spliceosome for first transesterification step; IBA:GO_Central; . GO GO:0001833; P:inner cell mass cell proliferation; IEA:Ensembl; . GO GO:0008610; P:lipid biosynthetic process; IEA:Ensembl; . GO GO:0000398; P:mRNA splicing; via spliceosome; IDA:UniProtKB GO GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl; . GO GO:0048711; P:positive regulation of astrocyte differentiation; IEA:Ensembl; . GO GO:0048026; P:positive regulation of mRNA splicing; via spliceosome; IEA:Ensembl GO GO:0010498; P:proteasomal protein catabolic process; IMP:UniProtKB; . GO GO:0070534; P:protein K63-linked ubiquitination; IMP:UniProtKB; . GO GO:0000209; P:protein polyubiquitination; IDA:MGI; . GO GO:0072422; P:signal transduction involved in DNA damage checkpoint; IMP:UniProtKB; . GO GO:0000245; P:spliceosomal complex assembly; IMP:BHF-UCL; . GO GO:0000244; P:spliceosomal tri-snRNP complex assembly; IDA:UniProtKB; . GO GO:0006283; P:transcription-coupled nucleotide-excision repair; TAS:Reactome; . Gene3D 2.130.10.10; -; 1; . Gene3D 3.30.40.10; -; 1; . InterPro IPR020472; G-protein_beta_WD-40_rep; . InterPro IPR013915; Pre-mRNA_splic_Prp19; . InterPro IPR000772; Ricin_B_lectin; . InterPro IPR003613; Ubox_domain; . InterPro IPR015943; WD40/YVTN_repeat-like_dom; . InterPro IPR001680; WD40_repeat; . InterPro IPR019775; WD40_repeat_CS; . InterPro IPR017986; WD40_repeat_dom; . InterPro IPR013083; Znf_RING/FYVE/PHD; . Pfam PF08606; Prp19; 1; . Pfam PF04564; U-box; 1; . Pfam PF00400; WD40; 5; . PRINTS PR00320; GPROTEINBRPT; . SMART SM00504; Ubox; 1; . SMART SM00320; WD40; 7; . SUPFAM SSF50978; SSF50978; 1; . PROSITE PS51698; U_BOX; 1; . PROSITE PS00678; WD_REPEATS_1; 1; . PROSITE PS50082; WD_REPEATS_2; 4; . PROSITE PS50294; WD_REPEATS_REGION; 1; .

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